Neural Correlates of Optimal Deep Brain Stimulation for Cervical Dystonia.
Aaron LohGavin J B EliasJürgen GermannAlexandre BoutetDave GwunKazuaki YamamotoCan SaricaPaula AzevedoAjmal ZemmarJessica PintoAsma NaheedSuneil K KaliaMojgan HodaieRenato P MunhozAndres M LozanoAlfonso FasanoPublished in: Annals of neurology (2022)
A total of 15 individuals with cervical dystonia and good outcome after pallidal deep brain stimulation underwent resting-state functional magnetic resonance imaging under three conditions: stimulation using a priori clinically determined optimal settings (ON-Op), non-optimal settings (ON-NOp), and stimulation off (OFF). ON-Op > OFF and ON-Op > ON-NOp were both associated with significant deactivation within sensorimotor cortex (changes not seen with ON-NOp > OFF). Brain responses to stimulation were related to individual long-term clinical improvement (R = 0.73, R 2 = 0.53, p = 0.001). The relationship was consistent when this model included four additional patients with generalized or truncal dystonia. These findings highlight the potential for immediate imaging-based biomarkers of clinical efficacy. ANN NEUROL 2022;92:418-424.
Keyphrases
- deep brain stimulation
- resting state
- functional connectivity
- parkinson disease
- obsessive compulsive disorder
- magnetic resonance imaging
- high resolution
- computed tomography
- risk assessment
- magnetic resonance
- climate change
- blood brain barrier
- contrast enhanced
- brain injury
- cerebral ischemia
- early onset
- fluorescence imaging