Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease.
Marie BleakleyAlison SehgalStuart SeropianMelinda A BiernackiElizabeth F KrakowAnn DahlbergHeather PersingerBarbara HilzingerPaul J MartinPaul A CarpenterMary Evelyn FlowersJenna VoutsinasTheodore A GooleyKeith R LoebBrent L WoodShelly HeimfeldStanley R RiddellWarren D ShlomchikPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
from PBSC allografts results in very low incidences of severe acute and any cGVHD, without apparent excess risks of relapse or nonrelapse mortality, distinguishing this novel graft engineering strategy from other hematopoietic cell transplantation approaches.