Rationale and Design of the Impact of Air Pollution Due to DESERT Dust in Patients with HEART Failure (DESERT HEART).
Alberto Domínguez-RodríguezPablo AvanzasNéstor Báez-FerrerPedro Abreu-GonzalezSergio RodríguezSebastian Matos-CastroDaniel Hernández-VaqueroPublished in: Journal of clinical medicine (2023)
The results of this study will test the hypothesis that exposure to high concentrations of Saharan dust affects the normal function of the respiratory epithelium due to the imbalance between the production of free radicals and antioxidant enzymes, thus causing increased pulmonary inflammation and oxidative stress in patients with HF that in turn may facilitate decompensations of their background disease condition.
Keyphrases
- oxidative stress
- air pollution
- health risk assessment
- health risk
- human health
- dna damage
- diabetic rats
- heart failure
- ischemia reperfusion injury
- pulmonary hypertension
- polycyclic aromatic hydrocarbons
- induced apoptosis
- fluorescent probe
- risk assessment
- sensitive detection
- heavy metals
- climate change
- living cells
- heat shock