Impact of Ethnicity-Specific Hepatic Microsomal Scaling Factor, Liver Weight, and Cytochrome P450 (CYP) 1A2 Content on Physiologically Based Prediction of CYP1A2-Mediated Pharmacokinetics in Young and Elderly Chinese Adults.

Guo-Fu LiQing-Shan ZhengYichao YuWei ZhongHong-Hao ZhouFurong QiuGuangji WangGuo YuHartmut Derendorf

Published in: Clinical pharmacokinetics (2020)

We provided quantitative information pertaining to Chinese-specific levels of liver weight and MPPGL, and recalibrated these system parameters for PBPK modeling for young and elderly Chinese subjects. Uncertainty surrounding the Chinese-specific CYP1A2 content has also been clarified. PBPK modeling based on the recalibrated system parameters can accurately simulate CYP1A2-mediated pharmacokinetics in both young and elderly Chinese adults, particularly in elderly individuals.

Keyphrases

middle aged
community dwelling
body mass index
physical activity
weight gain
healthcare
body weight