Kidney whole-transcriptome profiling in primary antiphospholipid syndrome reveals complement, interferons and NETs-related gene expression.

Maria G G TektonidouKleio-Maria VerrouHarikleia GakiopoulouMenelaos ManoloukosPanagiotis LembessisPantelis HatzisPetros P Sfikakis

Published in: Rheumatology (Oxford, England) (2024)

Complement, interferon and NETs-related genes are highly expressed in APS kidney tissues, similarly to SLE, pointing out the role of innate immunity in APS nephropathy pathogenesis and potential treatment targets.

Keyphrases

gene expression
single cell
systemic lupus erythematosus
dna methylation
rna seq
dendritic cells
genome wide
disease activity
rheumatoid arthritis
human health