Cross talk between Hsp72, HMGB1 and RAGE/ERK1/2 signaling in the pathogenesis of bronchial asthma in obese patients.
Nema Ali SolimanMuhammad Tarek Abdel GhafarReham Mohamed El KolaleyYasser Mostafa HafezRehab E Abo ElgheitMarwa Mohamed AtefPublished in: Molecular biology reports (2020)
The current study highlights the role of Hsp72 and HMGB1/RAGE/ERK1/2 signaling cascade in the pathogenesis of bronchial asthma and its link to obesity, which could be reflected on monitoring, severity grading, and management of this disease.
Keyphrases
- obese patients
- bariatric surgery
- heat shock protein
- chronic obstructive pulmonary disease
- signaling pathway
- lung function
- weight loss
- cell proliferation
- heat shock
- heat stress
- gastric bypass
- pi k akt
- roux en y gastric bypass
- insulin resistance
- allergic rhinitis
- metabolic syndrome
- type diabetes
- weight gain
- high fat diet induced
- skeletal muscle
- body mass index
- oxidative stress