Targeting the ZNF-148/miR-335/SOD2 signaling cascade triggers oxidative stress-mediated pyroptosis and suppresses breast cancer progression.

Yanmei WangYansi GongXuesha LiWeizhao LongJiayu ZhangJiefang WuYilong Dong

Published in: Cancer medicine (2023)

Our findings indicated that ZNF-148 promotes breast cancer progression by triggering miR-335/SOD2/ROS-mediated pyroptotic cell death and aid the identification of potential therapeutic targets for breast cancer.

Keyphrases

cell death
cell proliferation
oxidative stress
long non coding rna
dna damage
long noncoding rna
amyotrophic lateral sclerosis
signaling pathway
ischemia reperfusion injury
cancer therapy
risk assessment
cell cycle arrest
induced apoptosis
heat shock protein
heat stress