Reversible redox-responsive 1H/19F MRI molecular probes.

Hongming ChenXiaoxue TangXuanqing GongDongxia ChenAo LiChengjie SunHongyu LinJinhao Gao

Published in: Chemical communications (Cambridge, England) (2020)

Herein we report a pair of redox-responsive manganese complexes Mn(iii)/(ii)-N,N'-bis(2-hydroxy-4-trifluoromethylbenzyl)ethylenediamine-N,N'-diacetate (HTFBED, L1), which are water soluble and biologically interconvertible, as reversible redox-responsive probes in 1H/19F MRI for detecting and imaging biological redox species, offering a means to access valuable redox information associated with various diseases.

Keyphrases

water soluble
magnetic resonance imaging
small molecule
cancer therapy
contrast enhanced
electron transfer
single molecule
fluorescence imaging
high resolution
diffusion weighted imaging
nucleic acid
fluorescent probe