In silico Mechanics of Stem Cells Intramyocardially Transplanted with a Biomaterial Injectate for Treatment of Myocardial Infarction.
Y D MotchonKevin L SackM S SirryN J NchejaneTamer AbdalrahmanJ NagawaM KrugerElin PauwelsD Van LooA De MuynckLuc Van HoorebekeNeil Hamer DaviesThomas FranzPublished in: Cardiovascular engineering and technology (2024)
Combining the microstructural and biventricular finite element models enables quantifying micromechanics of transplanted cells in the heart. The approach offers a broader scope for in silico investigations of biomaterial and cell therapies for myocardial infarction and other cardiac pathologies.
Keyphrases
- stem cells
- left ventricular
- heart failure
- finite element
- molecular docking
- induced apoptosis
- cell therapy
- cardiac resynchronization therapy
- single cell
- cell cycle arrest
- atrial fibrillation
- endoplasmic reticulum stress
- tissue engineering
- cell death
- mesenchymal stem cells
- signaling pathway
- bone marrow
- multiple sclerosis
- replacement therapy