Lysobacter gummosus 10.1.1, a Producer of Antimicrobial Agents.
Irina KudryakovaAlexey AfoshinSergey V TarlachkovElena LeontyevskayaNatalia SuzinaNatalia Leontyevskaya VasilyevaPublished in: Microorganisms (2023)
This work investigated the antimicrobial potential of Lysobacter gummosus 10.1.1. The culture fluid of the strain was found to contain antimicrobial agents active against Staphylococcus aureus , Micrococcus luteus , and Bacillus cereus . L. gummosus was first shown to be capable of forming outer membrane vesicles, which have a bacteriolytic effect against not only Gram-positive bacteria but also against the Gram-negative pathogen Pseudomonas aeruginosa . Transcriptomic analysis revealed the genes of almost all known bacteriolytic enzymes of Lysobacter , as well as the genes of enzymes with putative bacteriolytic activity. Also identified were genes involved in the biosynthesis of a number of secondary metabolites for which antimicrobial activities are known. This research is indicative of the relevance of isolating and studying L. gummosus antimicrobial agents.
Keyphrases
- staphylococcus aureus
- gram negative
- pseudomonas aeruginosa
- multidrug resistant
- biofilm formation
- methicillin resistant staphylococcus aureus
- genome wide
- cystic fibrosis
- gene expression
- ms ms
- risk assessment
- dna methylation
- single cell
- climate change
- atomic force microscopy
- bioinformatics analysis
- single molecule
- genome wide identification