Lung Allograft Microbiome Association with Gastroesophageal Reflux, Inflammation, and Allograft Dysfunction.
Pierre H H SchneebergerChen Yang Kevin ZhangJessica SantilliBo ChenWei XuYoungho LeeZonelle WijesinhaElaine Reguera-NuñezNoelle YeeMusawir AhmedKristen BoonstraRayoun RamendraCourtney W FrankelScott M PalmerJamie L ToddTereza MartinuBryan CoburnPublished in: American journal of respiratory and critical care medicine (2022)
GERD was associated with a high bacterial density, Prevotella- and Veillonella-dominated CST1. CST3, but not CST1 or GERD, was associated with inflammation and early development of ALAD/CLAD. Nissen fundoplication was associated with reduction in microbial density in BALF samples, especially the CST1-specific genus, Prevotella. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).