Fulminant multiple sclerosis versus autoimmune encephalitis: A case report.

Early diagnosis and treatment of fulminant multiple sclerosis (MS), also known as Marburg' or malignant variant of MS (MVMS), is of great value in reducing morbidity and mortality. Seronegative autoimmune encephalitis (AIE) is very similar to, and sometimes indistinguishable from, fulminant MS. However, the acute and long-term management of the two diseases is often the same. This article describes the clinical course of a patient suspected of having MVMS or AIE and the challenges of their differential diagnosis and management.