Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects.
Armel H Nwabo KamdjePaul F Seke EtetRichard Tagne SimoLorella VecchioKiven Erique LukongMauro KramperaPublished in: Cancer biology & medicine (2020)
After more than a decade of controversy on the role of stromal cells in the tumor microenvironment, the emerging data shed light on pro-tumorigenic and potential anti-cancer factors, as well as on the roots of the discrepancies. We discuss the pro-tumorigenic effects of stromal cells, considering the effects of tumor drivers like hypoxia and tumor stiffness on these cells, as well as stromal cell-mediated adiposity and immunosuppression in the tumor microenvironment, and cancer initiating cells' cellular senescence and adaptive metabolism. We summarize the emerging data supporting stromal cell therapeutic potential in cancer, discuss the possibility to reprogram stromal cells of the tumor microenvironment for anti-cancer effects, and explore some causes of discrepancies on the roles of stromal cells in cancer in the available literature.
Keyphrases
- papillary thyroid
- squamous cell
- single cell
- induced apoptosis
- electronic health record
- bone marrow
- cell therapy
- big data
- lymph node metastasis
- systematic review
- cell cycle arrest
- metabolic syndrome
- adipose tissue
- insulin resistance
- type diabetes
- cell death
- risk assessment
- oxidative stress
- physical activity
- weight loss
- body mass index
- mesenchymal stem cells
- signaling pathway
- data analysis
- skeletal muscle
- stress induced