The crucial role of ZEB2: From development to epithelial-to-mesenchymal transition and cancer complexity.
Masoumeh FardiMohammad Reza AlivandBehzad BaradaranMajid Farshdousti HaghSaeed SolaliPublished in: Journal of cellular physiology (2019)
Zinc finger E-box binding homeobox 2 (ZEB2) is a DNA-binding transcription factor, which is mainly involved in epithelial-to-mesenchymal transition (EMT). EMT is a conserved process during which mature and adherent epithelial-like state is converted into a mobile mesenchymal state. Emerging data indicate that ZEB2 plays a pivotal role in EMT-induced processes such as development, differentiation, and malignant mechanisms, for example, drug resistance, cancer stem cell-like traits, apoptosis, survival, cell cycle arrest, tumor recurrence, and metastasis. In this regard, the understanding of mentioned subjects in the development of normal and cancerous cells could be helpful in cancer complexity of diagnosis and therapy. In this study, we review recent findings about the biological properties of ZEB2 in healthy and cancerous states to find new approaches for cancer treatment.
Keyphrases
- epithelial mesenchymal transition
- cell cycle arrest
- transcription factor
- dna binding
- cell death
- pi k akt
- signaling pathway
- long non coding rna
- papillary thyroid
- stem cells
- induced apoptosis
- cancer stem cells
- squamous cell
- squamous cell carcinoma
- oxidative stress
- binding protein
- endoplasmic reticulum stress
- big data
- machine learning
- childhood cancer
- lymph node metastasis
- deep learning
- cell therapy