Epiregulin promotes trophoblast epithelial-mesenchymal transition through poFUT1 and O-fucosylation by poFUT1 on uPA.

Xinyuan CuiHao WangYaqi LiTianhong ChenShuai LiuQiu Yan

Published in: Cell proliferation (2019)

Level of epiregulin and poFUT1 is lower in abortion patients than early pregnancy women. Epiregulin promotes trophoblast EMT through O-fucosylation on uPA catalysed by poFUT1. Epiregulin and poFUT1 may be suggested as the potential diagnostic biomarkers and useful treatment targets for abortion.

Keyphrases

epithelial mesenchymal transition
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
transforming growth factor
prognostic factors
polycystic ovary syndrome
signaling pathway
type diabetes
risk assessment
climate change