Flow-through versus static in vitro percutaneous penetration at 50 years: Possible relevance for bioequivalence.

Krishna AjjarapuHoward I Maibach

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2022)

Even though there was no consistent significant difference observed, labs have generally adapted to the method they regularly use, which is usually stated in their respective articles. Well-designed multicentered prospective comparative experiments should clarify potential advantages and disadvantages for each. For flow-through systems, the flow rate that most approximates to comparable in vivo data for animals and humans may be preferable.

Keyphrases

electronic health record
minimally invasive
big data
machine learning
ultrasound guided
risk assessment
artificial intelligence
radiofrequency ablation