Evaluation of Silver Nanoparticles Caffeic Acid Complex Compound as New Potential Therapeutic Agent against Cancer Incidence in Mice.
Tahany Saad AbdelwahabRania Ellisy AbdelhamedEman Noaman AliNahla Ahmed MansourMohga Shafik AbdallaPublished in: Asian Pacific journal of cancer prevention : APJCP (2021)
Nano-silver folate caffeic (NSFC) complex compound treatment resulted in growth inhibition in Ehrlich solid tumor, Hep-G2, and MCF-7 cells (IC50 0.062 mg, 7.70 µM, and 14.50 µM, respectively). Flow cytometric analysis revealed that (NSFC) with radiation IR had apoptotic effects at caspases 8 (Mean±SD) (49.4±14), caspase3 (39.97±9.75), and TNF (40.1±3.4) more than any other groups. Those disturbances were found to be associated with a kinetic induction of apoptosis and showed modulation of the antioxidant system {glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) which were 60.70±0.80, 26.73±0.80, 39.52±0.58 respectively}at the group which took (NSFC+IR), besides its high percentage of necrotic cells by histopathological studies. In conclusion, the present study showed that the treatment of (NSFC) exhibits very efficient oncolytic activity in delaying tumor growth in mice bearing Ehrlich Solid Carcinoma (ESC) and the mechanisms underlying the inhibitory effect of the present compound involve both an apoptotic effect against Hep-G2 and MCF-7 cells and modulation of antioxidant system.
Keyphrases
- cell cycle arrest
- induced apoptosis
- cell death
- oxidative stress
- silver nanoparticles
- endoplasmic reticulum stress
- anti inflammatory
- signaling pathway
- rheumatoid arthritis
- gold nanoparticles
- pi k akt
- breast cancer cells
- type diabetes
- papillary thyroid
- adipose tissue
- hydrogen peroxide
- risk factors
- high fat diet induced