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Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

Elizabeth TheuschFlora Y TingYuanyuan QinKristen StevensDevesh NaidooSarah M KingNeil V YangJoseph OrrBrenda Y HanJason G CysterYii-Der I ChenJerome I RotterRonald M KraussMarisa W Medina
Published in: Genome medicine (2024)
Our in vitro and in vivo studies identified ZNF335 as a novel modulator of plasma cholesterol levels and statin response, suggesting that variation in ZNF335 activity could contribute to inter-individual differences in statin clinical efficacy.
Keyphrases
  • low density lipoprotein
  • cardiovascular disease
  • coronary artery disease
  • single cell
  • case control
  • type diabetes
  • dna methylation