Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats.

Charissa E van den BromCaitlin BozicChantal A PoletAnnabel BongersAnita M Tuip-de BoerRoselique IbelingsJoris J T H RoelofsNicole P Juffermans

Published in: Molecular medicine (Cambridge, Mass.) (2024)

'Double hit' VILI was characterized by inflammation, impaired oxygenation, pulmonary edema and histopathological lung injury. Blocking CTGF does not improve oxygenation nor reduce pulmonary edema in rats with VILI.

Keyphrases

growth factor
pulmonary hypertension
oxidative stress
blood flow
diabetic rats
high glucose
acute respiratory distress syndrome
mechanical ventilation
drug induced
endothelial cells
intensive care unit