Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model.

Mitsuko KondoM TsujiK HaraK ArimuraO YagiE TagayaK TakeyamaJ Tamaoki

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)

Antigen challenge and Ca-dependent agonist treatment increased Cl ion transport via the overexpression of TMEM16A in goblet cell metaplasia in a guinea-pig asthma model. TMEM16A inhibitors may be useful for the treatment of hyper-secretion in asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
cell proliferation
transcription factor
stem cells
mesenchymal stem cells
replacement therapy