A phenome-wide scan reveals convergence of common and rare variant associations.
Dan ZhouYuan ZhouYue XuRan MengEric R GamazonPublished in: Genome medicine (2023)
The presented framework for the convergence signature has important implications for fine-mapping strategies and drug discovery efforts. In addition, our study provides a blueprint for the expectation from future large-scale whole-genome sequencing (WGS)/WES and sheds methodological light on post-GWAS studies.