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A phenome-wide scan reveals convergence of common and rare variant associations.

Dan ZhouYuan ZhouYue XuRan MengEric R Gamazon
Published in: Genome medicine (2023)
The presented framework for the convergence signature has important implications for fine-mapping strategies and drug discovery efforts. In addition, our study provides a blueprint for the expectation from future large-scale whole-genome sequencing (WGS)/WES and sheds methodological light on post-GWAS studies.
Keyphrases
  • drug discovery
  • computed tomography
  • high resolution
  • air pollution
  • magnetic resonance imaging
  • magnetic resonance
  • high density