Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy.
Ines GuixQi LiuMiguel Angel PujanaPatrick HaJosep PiulatsIsabel LinaresFerran GuedeaJian-Hua MaoAnn LazarJocelyn S ChapmanSue S YomAlan AshworthMary Helen Barcellos-HoffPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Association of the TGFβ and alt-EJ signatures with their biological response validates TGFβ competency as a key mediator of DNA repair that can be readily assayed by gene expression. The predictive value of βAltw supports its development to assist in clinical decision making.