APOE ε4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD.
Angelina J PolsinelliKathleen A LaneMohit K ManchellaPaige E LoganSujuan GaoLiana G Apostolova
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
The observed earlier AO in EOAD APOE ε4 non-carriers relative to carriers, particularly in females, suggests the presence of additional AD risk variants.