Exomic and epigenomic analysis of pulmonary blastoma.

Najmeh AlirezaieAnne-Laure ChongFelix K F KommossNelly SabbaghianJose Camacho ValenzuelaDylan PelletierJavad NadafShailesh B KolekarPradeesh SivapalanMark G EvansPaul S ThornerPierre-Olivier FisetAndreas von DeimlingWilliam D Foulkes

Published in: Lung cancer (Amsterdam, Netherlands) (2024)

We conclude somatic DICER1 pathogenic variants are the major driver of pulmonary blastoma and are likely to act in conjunction with CTNNB1 hotspot variants that are often present.

Keyphrases

copy number
pulmonary hypertension
genome wide
gene expression