β-blockers may be detrimental in frail patients with heart failure with preserved ejection fraction.
Shungo HikosoHirota KidaAkihiro SunagaDaisaku NakataniKatsuki OkadaTomoharu DohiYohei SotomiBolrathanak OeunTaiki SatoYuki MatsuokaTetsuhisa KitamuraTomomi YamadaHiroyuki KurakamiShunsuke TamakiMasahiro SeoMasamichi YanoTakaharu HayashiAkito NakagawaYusuke NakagawaTakahisa YamadaYoshio YasumuraYasushi Sakatanull nullPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
Use of β-blockers was significantly associated with worse prognosis specifically in patients with HFpEF and high CFS, but not in those with low CFS. Use of β-blockers in HFpEF patients with frailty may need careful attention.