Single protein encapsulated SN38 for tumor-targeting treatment.

Changjun J Yu Faqing HuangKinsley WangMengmeng LiuWarren A ChowXiang LingFengzhi LiJason L CauseyXiuzhen HuangGalen Cook-WiensXiaojiang Cui

Published in: Journal of translational medicine (2023)

SPESN38 complexes provide a water soluble SN38 formulation. SPESN38-5 and SPESN38-8 demonstrate better PK values, lower toxicity, and superior antitumor efficacy in mouse models, compared with irinotecan and DOX.

Keyphrases

water soluble
mouse model
drug delivery
cancer therapy
protein protein
binding protein
small molecule
amino acid