Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease.

Kumpal MadrasiRaibatak DasHafiz MohmmadabdulLin LinBradley T HymanDouglas A LauffenburgerMark W AlbersRobert A RissmanJohn M BurkeJoshua F ApgarLucia WilleLore GruenbaumFei Hua

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)

A QSP model can provide novel insights to clinical results. Our model explains the results of clinical trials and provides guidance for future therapeutic development.

Keyphrases

clinical trial
coronary artery disease
cognitive decline
molecular docking
drug induced