DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress.
Sufang ZhangErnest Y C LeeMarietta Y W T LeeDong ZhangPublished in: Animal models and experimental medicine (2022)
Our results indicate that when the DNA replication fork is blocked, POLDIP3 can be recruited to the stalled replication fork and functions to bridge the early DNA damage checkpoint response and the later replication fork repair/restart.