Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice.
Wei PanJinxiu ZhaoJiacheng WuDaxiang XuXianran MengPengfei JiangHongli ShiXing GeXiaoying YangMinmin HuPeng ZhangRenxian TangNathan NagaratnamKuiyang ZhengXu-Feng HuangYinghua YuPublished in: Microbiome (2023)
The present study provides the first evidence that DI improves cognition and brain function with significant beneficial effects via the gut-brain axis, suggesting that DI may serve as a novel drug for treating obesity-associated neurodegenerative diseases. Video Abstract.
Keyphrases
- high fat diet
- white matter
- insulin resistance
- resting state
- cognitive impairment
- high fat diet induced
- adipose tissue
- functional connectivity
- metabolic syndrome
- type diabetes
- cerebral ischemia
- biofilm formation
- multiple sclerosis
- weight loss
- mild cognitive impairment
- mouse model
- body mass index
- skeletal muscle
- staphylococcus aureus
- pseudomonas aeruginosa