Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer.
Mikkel Morsing BaggerJonas SjölundJiyoung KimKatharina Theresa KohlerRené VilladsenAbbas JafariMoustapha KassemKristian PietrasLone Rønnov-JessenOle William PetersenPublished in: Breast cancer research : BCR (2024)
We propose that iCAFs and myCAFs originate in interlobular and lobular fibroblasts, respectively, and more importantly, that the tumor-promoting properties of lobular fibroblasts render the TDLU an epicenter for breast cancer evolution.