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Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer.

Mikkel Morsing BaggerJonas SjölundJiyoung KimKatharina Theresa KohlerRené VilladsenAbbas JafariMoustapha KassemKristian PietrasLone Rønnov-JessenOle William Petersen
Published in: Breast cancer research : BCR (2024)
We propose that iCAFs and myCAFs originate in interlobular and lobular fibroblasts, respectively, and more importantly, that the tumor-promoting properties of lobular fibroblasts render the TDLU an epicenter for breast cancer evolution.
Keyphrases
  • extracellular matrix
  • induced apoptosis
  • endothelial cells
  • cell cycle arrest
  • induced pluripotent stem cells
  • oxidative stress
  • signaling pathway
  • cell death
  • endoplasmic reticulum stress
  • wound healing