Neurodevelopmental and genetic determinants of exposure to adversity among youth at risk for mental illness.

Alyson ZwickerLynn E MacKenzieVladislav DrobininAmina M BagherEmily Howes VallisLukas PropperAlexa BagnellSabina AbidiBarbara PavlovaMartin AldaEileen M Denovan-WrightRudolf Uher

Published in: Journal of child psychology and psychiatry, and allied disciplines (2019)

A genetic score indexing liability to ADHD was associated with exposure to adversity in early life. Previously observed associations between externalizing symptoms, lower cognitive ability and adversity may be partially attributed to genetic liability to ADHD.

Keyphrases

early life
mental illness
attention deficit hyperactivity disorder
genome wide
mental health
autism spectrum disorder
working memory
copy number
physical activity
gene expression
dna methylation
depressive symptoms