Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model.

Melisa B NicoudMónica A Táquez DelgadoMaría de la Paz SarasolaAgustina VidalDaniela SpeiskyGraciela A CremaschiHelena A SterleVanina A Medina

Published in: Cancer immunology, immunotherapy : CII (2020)

H4R-mediated mechanisms may modulate the immune tumour microenvironment, promoting an immunosuppressive milieu. Results suggest that H4R could be explored as an immunotherapeutic target with potential benefit in combination with immunotherapy. Further preclinical and clinical studies are necessary to confirm this hypothesis.

Keyphrases

stem cells
human health
replacement therapy
binding protein
mesenchymal stem cells
climate change
bone marrow
breast cancer risk
smoking cessation
childhood cancer