CSF Cytokines and Chemokines Involved in Cytotoxic Cell Function and Risk of Acute 14-Day Mortality in Persons with Advanced HIV and Cryptococcal Meningitis.
Elizabeth C OkaforLiliane MukaremeraKathy H HullsiekNicole W EngenLillian TugumeKenneth SsebambuliddeAbdu MusubireEdwin NuwagiraEdward MpozaDarlisha A WilliamsConrad MuzooraJoshua RheinDavid B MeyaKirsten NielsenDavid R Boulwarenull nullPublished in: The Journal of infectious diseases (2024)
Proinflammatory and cytotoxicity-associated cytokine and chemokine responses in the CSF decrease the risk of acute 14-day mortality. These data suggest that a cytotoxic immune environment in the CSF could potentially improve acute survival. Further research on cytotoxic cells is crucial to improve understanding of innate and adaptive immune responses in cryptococcal meningitis.
Keyphrases
- liver failure
- immune response
- respiratory failure
- aortic dissection
- drug induced
- cardiovascular events
- human immunodeficiency virus
- hepatitis b virus
- antiretroviral therapy
- extracorporeal membrane oxygenation
- dendritic cells
- hiv aids
- signaling pathway
- toll like receptor
- cell proliferation
- inflammatory response
- coronary artery disease
- mechanical ventilation
- cell cycle arrest
- artificial intelligence
- hiv testing
- acute respiratory distress syndrome
- men who have sex with men