Chronic systemic corticosteroid therapy influences the development of pulp necrosis and experimental apical periodontitis, exacerbating the inflammatory process and bone resorption in rats.
Isabelly Vidal do NascimentoMaria Imaculada de Queiroz RodriguesPedro Henrique Chaves IsaiasPaulo Goberlânio de Barros SilvaFabrício Bitú SousaAna Paula Negreiros Nunes AlvesMário Rogério Lima MotaPublished in: International endodontic journal (2022)
The glucocorticoids modified the development of experimental apical periodontitis induced in rats, causing an early increase in periapical bone resorption and pulp necrosis. These effects are associated with alterations in cytokine levels, in the inflammatory response and in collagen deposition, in the 14th day after injury induction.