Nongenetic Precise Neuromodulation and Spatiotemporal Neuroprotection for Epilepsy Therapy via Rationally Designed Multifunctional Nanotransducer.
Qinjuan RenHaofan WuYa ZhangJing DaiZhiqiang ChangJianfang NieBingfang WangYin FangPublished in: ACS nano (2024)
The precise modulation of electrical activity in specific neuronal populations is paramount for rectifying abnormal neurological functions and is a critical element in the therapeutic arsenal for neurological disorders. However, achieving a balance between minimal invasiveness and robust neuroprotection poses a considerable challenge. Herein, we present a nanoneuromodulation strategy integrating neuroprotective features to effectively address epilepsy with minimal invasiveness and enable wireless functionality. Strategically engineered nanotransducer, adorned with platinum (Pt) decoration with titanium disulfide (TiS 2 ) (TiS 2 /Pt), enables precise modulation of neuronal electrical activity in vitro and in vivo , ensuring exceptional temporal fidelity under millisecond-precision near-infrared (NIR) light pulses irradiation. Concurrently, TiS 2 /Pt showcase a pronounced enhancement in enzyme-mimicking activity, offering a robust defense against oxidative neurological injury in vitro . Nanotransducer-enabled wireless neuromodulation with biocatalytic neuroprotective capacity is highly effective in alleviating epileptic high-frequency neural activity and diminishing oxidative stress levels, thereby restoring redox equilibrium. This integrated therapeutic approach reduces the severity of epilepsy, demonstrating minimal invasiveness and obviating the requirements for genetic manipulation and optical fiber implantation, while providing an alternative avenue for neurological disorder treatment.
Keyphrases
- cerebral ischemia
- high frequency
- subarachnoid hemorrhage
- oxidative stress
- brain injury
- blood brain barrier
- transcranial magnetic stimulation
- drug delivery
- stem cells
- high resolution
- dna damage
- photodynamic therapy
- mass spectrometry
- bone marrow
- dna methylation
- gene expression
- molecular dynamics
- molecular dynamics simulations
- cancer therapy
- fluorescence imaging
- cell therapy
- heat shock
- genome wide
- combination therapy
- heat shock protein
- fluorescent probe
- innate immune