Assessing the colonic microbiome, hydrogenogenic and hydrogenotrophic genes, transit and breath methane in constipation.
P G WolfG ParthasarathyJ ChenH M O'ConnorN ChiaAdil E BharuchaH R GaskinsPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)
Corroborating our earlier findings with 16S rRNA genes, colonic mucosal but not fecal hydrogenogenic and hydrogenotrophic genes were more abundant in constipated vs. healthy subjects independent of colonic transit. Breath gases do not directly reflect the abundance of target genes contributing to their production.