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Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs.

Arvind SharmaKanika AroraHarapriya MohapatraRakesh K SindhuMadalin BulzanDaniela Simona CavaluGulsheen PanesharHosam O ElansaryAhmed M El-SabroutEman A MahmoudAbdullah Alaklabi
Published in: Molecules (Basel, Switzerland) (2022)
At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt formation, and many more. One promising avenue attaining attention presently is supersaturated drug delivery systems. When exposed to gastrointestinal fluids, drug concentration exceeds equilibrium solubility and a supersaturation state is maintained long enough to be absorbed, enhancing bioavailability. In this review, the latest developments in supersaturated drug delivery systems are addressed in depth.
Keyphrases
  • water soluble
  • working memory
  • drug delivery
  • molecular dynamics
  • molecular dynamics simulations
  • drug release