Evidence of diabetes-specific autoimmunity in obese subjects with normal glucose tolerance.

Claudio TibertiSimona ZampettiDanila CapocciaGiuseppe CampagnaFederica LucantoniEmanuela AnastasiLucia PallottaFrancesca PanimolleGaetano LetoAndrea LenziFrida LeonettiRaffaella Buzzetti

Published in: Diabetes/metabolism research and reviews (2018)

We observed significant evidence of immunoreactivity specific to diabetes, thyroid, and gastric-parietal cells in obese patients with NGT. The relatively higher frequency of the diabetes-related IA-2(256-760) autoantibodies in obese patients with NGT may suggest that this autoantibody could be associated with obesity the presence of obesity itself.

Keyphrases

type diabetes
weight loss
metabolic syndrome
glycemic control
insulin resistance
cardiovascular disease
adipose tissue
bariatric surgery
induced apoptosis
obese patients
high fat diet induced
systemic lupus erythematosus
working memory
cell cycle arrest
signaling pathway
pi k akt