Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior.
Monica BaroneSilvia GarelliSimone RampelliAlessandro AgostiniSilke MatysikFederica D'AmicoSabrina KrautbauerRoberta MazzaNicola SalituroFlaminia FanelliPatricia IozzoYolanda SanzMarco CandelaPatrizia BrigidiUberto PagottoSilvia TurroniPublished in: BMC medicine (2022)
By finding peculiar gut microbiome profiles associated with eating patterns, we laid the foundation for elucidating gut-brain axis communication in the obese phenotype. Subject to confirmation of the hypotheses herein generated, our work could help guide the design of microbiome-based precision interventions, aimed at rewiring microbial networks to support a healthy diet-microbiome-gut-brain axis, thus counteracting obesity and related complications.
Keyphrases
- weight loss
- bariatric surgery
- resting state
- physical activity
- white matter
- functional connectivity
- obese patients
- weight gain
- polycystic ovary syndrome
- metabolic syndrome
- microbial community
- cerebral ischemia
- adipose tissue
- risk factors
- single cell
- insulin resistance
- genome wide
- multiple sclerosis
- body mass index
- pregnancy outcomes
- dna methylation
- pregnant women
- breast cancer risk
- finite element