Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia.

Zhipeng SunLuqi WangLu HanYue WangYuan ZhouQiang LiYongquan WuShaletanati TalabiekeYun-Long HouLulin WuRonghua LiuZhiping FuHongjie YouBai-Yan LiYuanyuan ZhengDali Luo

Published in: Circulation (2021)

Casq1 is expressed in the heart, where it regulates sarcoplasmic reticulum Ca2+ release and heart rate. Casq1 deficiency independently causes MH/EHS-like ventricular arrhythmia by trigger-induced Casq1 oligomerization and a relief of its inhibitory effect on ryanodine receptor-2-mediated Ca2+ release, thus revealing a new inherited arrhythmia and a novel mechanism for MH/EHS arrhythmogenesis.

Keyphrases

heart rate
catheter ablation
atrial fibrillation
heart failure
heart rate variability
blood pressure
replacement therapy
high glucose
protein kinase
drug induced
diabetic rats
smoking cessation