Effect of clomiphene citrate treatment on the Sertoli cells of dysmetabolic obese men with low testosterone levels.

Carla PelusiFlaminia FanelliMargherita BacciniVincenzo TriggianiBartolomeo NicolaMatteo Domenico CarboneGiovanni De PergolaGuido Di DalmaziUberto PagottoRenato PasqualiVito Angelo Giagulli

Published in: Clinical endocrinology (2019)

Unlike the LC activity, CC was unable to influence SC function, as shown by the lack of IB and AMH serum modifications, thus suggesting an intrinsic nonreversible defect of SC cells in patients with dysmetabolic conditions.

Keyphrases

induced apoptosis
cell cycle arrest
type diabetes
metabolic syndrome
adipose tissue
endoplasmic reticulum stress
oxidative stress
weight loss
signaling pathway
bariatric surgery
combination therapy
solid phase extraction