The synthesis of diarylamine is extremely important in organic chemistry. Herein, a novel electrochemical reductive arylation of nitroarenes with arylboronic acids was developed. A variety of diarylamines were synthesized without the need for transition-metal catalysts. The reaction could be scaled up efficiently in a flow cell and several derivatization reactions were carried out smoothly. Cyclic voltammetry experiments and mechanism studies showed that acetonitrile, formic acid, and triethyl phosphite all played a role in promoting this reductive arylation transformation.
Keyphrases
- transition metal
- gold nanoparticles
- molecularly imprinted
- ionic liquid
- label free
- single cell
- ms ms
- cell therapy
- electron transfer
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- solid phase extraction
- stem cells
- tandem mass spectrometry
- drug discovery
- high resolution
- ultra high performance liquid chromatography
- metal organic framework
- oxide nanoparticles