Bi-component T1ρ and T2 Relaxation Mapping of Skeletal Muscle In-Vivo.
Azadeh SharafiGregory ChangRavinder R RegattePublished in: Scientific reports (2017)
The goal of this paper was to evaluate the possibility of bi-component T1ρ and T2 relaxation mapping of human skeletal muscle at 3 T in clinically feasible scan times. T1ρ- and T2-weighted images of calf muscle were acquired using a modified 3D-SPGR sequence on a standard 3 T clinical MRI scanner. The mono- and biexponential models were fitted pixel-wise to the series of T1ρ and T2 weighted images. The biexponential decay of T1ρ and T2 relaxations was detected in ~30% and ~40% of the pixels across all volunteers, respectively. Monoexponential and bi-exponential short and long T1ρ relaxation times were estimated to be 26.9 ms, 4.6 ms (fraction 22%) and 33.2 ms (fraction: 78%), respectively. Similarly, the mono- and bi-exponential short and long T2 relaxation times were 24.7 ms, 4.2 ms (fraction 15%) and 30.4 ms (fraction 85%) respectively. The experiments had good repeatability with RMSCV < 15% and ICC > 60%. This approach could potentially be used in exercise intervention studies or in studies of inflammatory myopathies or muscle fibrosis, permitting greater sensitivity and specificity via measurement of different water compartments and their fractions.
Keyphrases
- skeletal muscle
- ms ms
- diffusion weighted imaging
- contrast enhanced
- single molecule
- insulin resistance
- deep learning
- high resolution
- mass spectrometry
- magnetic resonance
- convolutional neural network
- multiple sclerosis
- endothelial cells
- liquid chromatography tandem mass spectrometry
- magnetic resonance imaging
- computed tomography
- optical coherence tomography
- network analysis
- case control
- physical activity
- high density
- high performance liquid chromatography
- oxidative stress
- metabolic syndrome
- machine learning
- high intensity
- structural basis