N-myc Downstream-Regulated Gene 1 (NDRG1) Regulates Vascular Endothelial Growth Factor A (VEGFA) and Malignancies in Glioblastoma Multiforme (GBM).

Xufan ZhangQian ChenYu-Chen LiHongqing ChenQin Jiang Qiong-Ying Hu

Published in: BioMed research international (2022)

NDRG1-induced VEGFA exerts protective effects in GBM via the VEGFA/VEGFR2 pathway. Therefore, targeting both NDRG1 and VEGFA may represent a novel therapy for the treatment of GBM.

Keyphrases

vascular endothelial growth factor
endothelial cells
transcription factor
high glucose
genome wide
cancer therapy
oxidative stress