Evaluation of family history in individuals with heterozygous BRCA pathogenic variants diagnosed with breast or ovarian cancer in a single center in Italy.

Serena NegriElena De PontiFederica Paola SinaElena SalaCristina Dell'OroGaia RoversiSara LazzarinMartina Delle MarchetteAlesssandra InzoliClaudia TosoSimona FumagalliMaria CampanellaJoanne KotsopoulosRobert Fruscio

Published in: Molecular genetics & genomic medicine (2022)

FH is a powerful tool to identify high-risk individuals eligible for genetic counseling and testing. Testing of healthy individuals should be considered when an appropriately affected family member is unavailable for testing.

Keyphrases

copy number
gene expression
smoking cessation