Blood purification therapy is widely used in patients with renal insufficiency and severe infections, where membrane-associated thrombosis is a side effect. How to improve the hemocompatibility of dialysis membranes and reduce thrombosis is a focus of current research, in which platelets play a key role. However, few dialysis membranes that directly inhibit platelets have been developed to date. In this study, a polyethersulfone (PES) membrane was modified with ticagrelor, a platelet P2Y 12 receptor inhibitor, and detailed characterization was performed. The ticagrelor modified PES membrane (TMPES) showed good hydrophilicity and anti-protein adsorption and significantly inhibited platelet adhesion, aggregation, and activation, which demonstrated good antithrombotic properties. In addition, the membrane had excellent red blood cell (RBC) compatibility, anticoagulant, and antiinflammatory effects, which demonstrated superior biosafety in cell and animal experiments. Therefore, the TMPES dialysis membrane could have potential in clinical applications.
Keyphrases
- red blood cell
- chronic kidney disease
- acute coronary syndrome
- end stage renal disease
- percutaneous coronary intervention
- atrial fibrillation
- pulmonary embolism
- antiplatelet therapy
- st segment elevation myocardial infarction
- venous thromboembolism
- small molecule
- early onset
- peritoneal dialysis
- cell therapy
- bone marrow
- escherichia coli
- drug induced