Pregnancy management and outcome in patients with four different tetrahydrobiopterin disorders.
Oya Kuseyri HübschmannA WeissbachN BruggemannC KleinM GiżewskaD KarallS Scholl-BürgiH RomanowskaE Krzywińska-ZdebA A MonavariI KnerrZ YapıcıV LeuzziT OpladenPublished in: Journal of inherited metabolic disease (2018)
Although our data on 16 pregnancies in seven patients did not present any association of standard drug treatment with an increased rate of pregnancy complications, abnormal obstetrical or paediatric outcome, an intensive clinical and biochemical supervision by a multidisciplinary team before, during and after the pregnancy in any BH4 deficiency is essential since available data on pregnancies in patients with BH4 deficiencies is limited.
Keyphrases
- preterm birth
- pregnancy outcomes
- end stage renal disease
- electronic health record
- ejection fraction
- gestational age
- chronic kidney disease
- newly diagnosed
- pregnant women
- emergency department
- big data
- intensive care unit
- peritoneal dialysis
- prognostic factors
- palliative care
- risk factors
- patient reported outcomes
- data analysis
- adverse drug