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Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms: A cross-sectional study.

Sanobar ShariffHalah A NouhSamuel InshutiyimanaCharbel KachouhMaya Magdy AbdelwahabAbubakar NazirMagda WojtaraOlivier Uwishema
Published in: Health science reports (2024)
Understanding epileptogenesis at a molecular and genetic level aids in developing new antiepileptic pharmacotherapy. The aim is to develop therapies that could prevent seizures or modify disease course, decreasing the severity and avoiding drug resistance. Gene therapy and precision medicine are promising but applications are limited due to the heterogeneity in studying the Epileptic brain, dynamically. The dynamic investigation of the epileptic brain with its comorbidities works hand-in-hand with precision medicine, in developing personalized treatment plans.
Keyphrases
  • gene therapy
  • resting state
  • white matter
  • temporal lobe epilepsy
  • functional connectivity
  • physical activity
  • cerebral ischemia
  • single cell
  • genome wide
  • risk factors
  • gene expression
  • dna methylation
  • combination therapy