Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
Thai H TranFransiscus E UtamaTakahiro SatoAmy R PeckJohn F LangenheimSameer S UdhaneYunguang SunChengbao LiuMelanie A GirondoAlbert J KovatichJeffrey A HookeCraig D ShriverHai HuJuan P PalazzoMarluce BibboPaul W AuerMichael J FlisterTerry HyslopEdith P MitchellInna ChervonevaHallgeir RuiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
This study overturns the prevailing view that PTHrP is upregulated in primary breast cancers and identifies a direct prolactin-Stat5-PTHrP axis that is progressively lost in more aggressive tumors.