Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells.

Shuang ZhangJeroen van de PeppelMarijke KoedamJohannes P T M van LeeuwenBram C J van der Eerden

Published in: Cellular and molecular life sciences : CMLS (2023)

Here, we identify TNS3 to be involved in BMSC fate decision. Our study links the domain structure in TNS3 to RhoA activity via actin dynamics and implicates an important role for TNS3 in regulating osteogenesis and adipogenesis from BMSCs. Furthermore, it supports the critical involvement of cytoskeletal reorganization in BMSC differentiation.

Keyphrases

bone marrow
mesenchymal stem cells
endothelial cells
induced pluripotent stem cells
skeletal muscle
metabolic syndrome